DrBeen#49 Norepinephrine, Glymphatic System, and Brain Health

DrBeen#49 Norepinephrine, Glymphatic System, and Brain Health During the wakeful hours, the production of norepinephrine increases. This increase helps with alertness, but also causes vasoconstriction. The outcome is a reduction in the interstitial fluid levels and reduction in the clearance of waste products. During sleep, NE levels reduce, reversing the above mentioned mechanisms, leading to more interstitial fluid movement and more glymphatic clearance of the waste products and better brain health. DrBeen: Medical Education Onlinehttps://www.drbeen.com/ FLCCC | Front Line COVID-19 Critical Care Alliancehttps://covid19criticalcare.com/ URL list from Monday, Feb. 20 2023 The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices - PMChttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698404/ Norepinephrine: What It Is, Function, Deficiency & Side Effectshttps://my.clevelandclinic.org/health/articles/22610-norepinephrine-noradrenaline#:~:text=What%20does%20norepinephrine%20do%20in,pressure%20in%20times%20of%20stress. Frontiers | Locus Coeruleus Norepinephrine in Learned Behavior: Anatomical Modularity and Spatiotemporal Integration in Targetshttps://www.frontiersin.org/articles/10.3389/fncir.2021.638007/full#:~:text=The%20locus%20coeruleus%20(LC)%2C,%2C%20cerebellum%2C%20and%20spinal%20cord. fncir-15-638007-g001.jpg (1700×984)https://www.frontiersin.org/files/Articles/638007/fncir-15-638007-HTML/image_m/fncir-15-638007-g001.jpg Sleep well — and reduce your risk of dementia and death - Harvard Healthhttps://www.health.harvard.edu/blog/sleep-well-and-reduce-your-risk-of-dementia-and-death-2021050322508 APOE ε4, Alzheimer’s disease neuropathology and sleep disturbance, in individuals with and without dementia | Alzheimer's Research & Therapy | Full Texthttps://alzres.biomedcentral.com/articles/10.1186/s13195-022-00992-y N3 Phase of Sleep.https://chat.openai.com/chat Understanding Delta Brain Waves And Sleephttps://www.sixstepstosleep.com/understanding-delta-brain-waves/ N3: Slow Wave Sleep | Sleepopolishttps://sleepopolis.com/education/n3-slow-wave-sleep/ Stage N3 of sleep. Delta waves on EEG recordings are observed.  | Download Scientific Diagramhttps://www.researchgate.net/figure/Stage-N3-of-sleep-Delta-waves-on-EEG-recordings-are-observed_fig4_280558638 A 30-second Epoch consisting of the parameters of staging sleep... | Download Scientific Diagramhttps://www.researchgate.net/figure/4-A-30-second-Epoch-consisting-of-the-parameters-of-staging-sleep-electroencephalogram_fig4_282014972 Hallmark of Stage N3 (slow-wave sleep or Stages 3 and 4 sleep: delta... | Download Scientific Diagramhttps://www.researchgate.net/figure/Hallmark-of-Stage-N3-slow-wave-sleep-or-Stages-3-and-4-sleep-delta-waves_fig1_5812861 Frontiers | Perivascular Spaces, Glymphatic System and MRhttps://www.frontiersin.org/articles/10.3389/fneur.2022.844938/full Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular pathology | SpringerLinkhttps://link.springer.com/article/10.1007/s00234-021-02718-7 Frontiers | Perivascular Unit: This Must Be the Place. The Anatomical Crossroad Between the Immune, Vascular and Nervous Systemhttps://www.frontiersin.org/articles/10.3389/fnana.2020.00017/full Neuroglia Lab : Glymphatics and virchow-robin spacehttp://visnu528.blogspot.com/2014/09/glymphatics-and-virchow-robin-space.html Physiology and Clinical Relevance of Enlarged Perivascular Spaces in the Aging Brain | Neurologyhttps://n.neurology.org/content/98/3/107 Aquaporin-4 - Wikipediahttps://en.wikipedia.org/wiki/Aquaporin-4 Astrocyte - Wikipediahttps://en.wikipedia.org/wiki/Astrocyte Neurocytology-Astrocyteshttps://neuropathology-web.org/chapter1/chapter1bAstrocytes.html#:~:text=Astrocytic%20foot%20processes%20surround%20brain,maintains%20homeostasis%20in%20the%20CNS. Disclaimer As per previous episodes